British Airways will resume its non-stop service between Heathrow and Phoenix, Arizona, at the end of the month.
Direct flights will begin again on August 31, after being suspended in March 2020 because of the pandemic.
The three-times-weekly service sees flights leave Heathrow at 14.15, landing in Phoenix at 17.05. Return flights depart at 19.15, landing in London at 13.15 on the following day.
Flights will take 10 hours, 50 minutes and will be operated by a three-class B777-200.
US arrivals who are fully vaccinated against Covid-19 can enter the UK without having to quarantine but British leisure travellers are still banned from entering the US.
Kate Gallego, Phoenix mayor, said: “British Airways has been a key partner to the city of Phoenix and Sky Harbor International Airport for more than 20 years.
“This flight will contribute to the growth of our economy, while providing travellers with a non-stop connection to Europe.”
Last month BA added extra capacity to the US after bookings almost doubled within hours of the UK government announcement that vaccinated US arrivals to England would no longer need to quarantine.
It put on extra seats to New York, Los Angeles and Chicago.